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Article

Novel subtypes of metabolic associated steatotic liver disease linked to clinical outcomes: implications for precision medicine.

Journal of translational medicine - 10 Jul 2025

Hong Chang, Liang Sheng-Xing, Li Ze-Yang, Li Rui-Ning, Zhu Hong-Bo, He Mingfei, Cui Hao, He Jing-Zhe, Li Yan, Wang Jia-Ren, Zou Xue-Jing, Li Wen-Yuan, Zeng Lin, Liu Li, Xiao Lu-Shan

Abstract excerpt

BACKGROUND & AIMS: Although metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with high multimorbidity and mortality, existing classification systems and risk prediction models largely ignore the heterogeneity of MASLD. Improved subtype definition could improve prediction of outcomes and inform new precision treatment strategies. METHODS: We analyzed individuals with MASLD from...

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PMID: 40640848
DOI: 10.1186/s12967-025-06670-5
PMCID: PMC12247398

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