Genetic Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease.

doi:10.5009/gnl240407

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Article

Genetic Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease.

Gut and liver - 15 Jan 2025

Pei Yiying, Goh George Boon-Bee

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common cause of liver disease, and its burden on health systems worldwide continues to rise at an alarming rate. MASLD is a complex disease in which the interactions between susceptible genes and the environment influence the disease phenotype and severity. Advances in human genetics over the past few decades have provided new...

Topics

Humans
Genetic Predisposition to Disease
Risk Factors
Polymorphism, Single Nucleotide
Fatty Liver
Membrane Proteins
Lipase
Acyltransferases
17-Hydroxysteroid Dehydrogenases
Adaptor Proteins, Signal Transducing
Obesity
Phospholipases A2, Calcium-Independent

Source

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Identifiers

PMID: 39774124
DOI: 10.5009/gnl240407
PMCID: PMC11736312

Genes

GCKR
HSD17B13
MBOAT7
PNPLA3

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