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Article

iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.

Cell reports - 20 Nov 2014

Woodard Chris M, Campos Brian A, Kuo Sheng-Han, Nirenberg Melissa J, Nestor Michael W, Zimmer Matthew, Mosharov Eugene V, Sulzer David, Zhou Hongyan, Paull Daniel, Clark Lorraine, Schadt Eric E, Sardi Sergio Pablo, Rubin Lee, Eggan Kevin, Brock Mathew, Lipnick Scott, Rao Mahendra, Chang Stephen, Li Aiqun, Noggle Scott A

Abstract excerpt

Parkinson's disease (PD) has been attributed to a combination of genetic and nongenetic factors. We studied a set of monozygotic twins harboring the heterozygous glucocerebrosidase mutation (GBA N370S) but clinically discordant for PD. We applied induced pluripotent stem cell (iPSC) technology for PD disease modeling using the twins' fibroblasts to evaluate and dissect the genetic and nongenetic contributions....

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Source

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Identifiers

PMID: 25456120
DOI: 10.1016/j.celrep.2014.10.023
PMCID: PMC4255586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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