Article

Structures of ferroportin in complex with its specific inhibitor vamifeport

2022-08-29

Abstract excerpt

A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe 2+ transport and induces internalization and degradation of FPN. Dysregulation of the FPN/hepcidin axis leads to diverse pathological conditions, and consequently, pharmacological compounds that inhibit FPN-mediated iron transport are of high...

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Literature Corpus work: 27eb32a0-21ad-5a4b-a36f-29a99f2637d5
DOI: 10.1101/2022.08.29.505642

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