Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The factors governing the thermal stability of frataxin orthologues: how to increase a protein's stability.

Biochemistry - 1 Jun 2004

Adinolfi Salvatore, Nair Margie, Politou Anastasia, Bayer Elena, Martin Stephen, Temussi Pierandrea, Pastore Annalisa

Abstract excerpt

Understanding the factors governing the thermal stability of proteins and correlating them to the sequence and structure is a complex and multiple problem that can nevertheless provide important information on the molecular forces involved in protein folding. Here, we have carried out a comparative genomic study to analyze the effects that different intrinsic and environmental factors have on the thermal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular Dichroism
Share to Frataxin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iron-Binding Proteins

Share to Magnetic Resonance Spectroscopy

Share to Structural Homology, Protein

Share to Structure-Activity Relationship

Share to Thermodynamics

Source

Identifiers

PMID: 15157084
DOI: 10.1021/bi036049+

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The factors governing the thermal stability of frataxin orthologues: how to increase a protein's stability.PMID 15157084Read ↗

Thermodynamic Stabilization of Human FrataxinSemantic proximity Read ↗

Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region.Semantic proximity Read ↗

The structure and function of frataxin.Semantic proximity Read ↗

Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding.Semantic proximity Read ↗

Frataxin: a protein in search for a function.Semantic proximity Read ↗

Understanding the binding properties of an unusual metal-binding protein--a study of bacterial frataxin.Semantic proximity Read ↗

Conformational stability, dynamics and function of human frataxin: Tryptophan side chain interplay.Semantic proximity Read ↗

An In Silico Analysis of Genetic Variants and Structural Modeling of the Human Frataxin Protein in Friedreich's Ataxia.Semantic proximity Read ↗

Neurodegeneration in Friedreich’s Ataxia: From Defective Frataxin to Oxidative StressSemantic proximity Read ↗

Insights on the conformational dynamics of human frataxin through modifications of loop-1.Semantic proximity Read ↗

Selection of Synthetic Proteins to Modulate the Human Frataxin FunctionSemantic proximity Read ↗

Nanobodies as Novel Tools to Modulate Human Frataxin Stability and FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.