Article

Thermodynamic Stabilization of Human Frataxin

2023-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Recombinant proteins and antibodies are routinely used as drugs to treat prevalent diseases such as diabetes or cancer, while enzyme replacement and gene therapies are the main therapeutic intervention lines in rare diseases. In protein-based therapeutics, optimized in vivo stability is key as intrinsic denaturation and intracellular proteostatic degradation will limit potency, particularly in...

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Literature Corpus work: 3e1554e7-b8dc-5922-87b2-abd4b851e43c
DOI: 10.1101/2023.09.08.556816

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