Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma.

doi:10.1016/j.ccell.2016.05.004

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Article

Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma.

Cancer cell - 11 Jul 2016

Hedegaard Jakob, Lamy Philippe, Nordentoft Iver, Algaba Ferran, Høyer Søren, Ulhøi Benedicte Parm, Vang Søren, Reinert Thomas, Hermann Gregers G, Mogensen Karin, Thomsen Mathilde Borg Houlberg, Nielsen Morten Muhlig, Marquez Mirari, Segersten Ulrika, Aine Mattias, Höglund Mattias, Birkenkamp-Demtröder Karin, Fristrup Niels, Borre Michael, Hartmann Arndt, Stöhr Robert, Wach Sven, Keck Bastian, Seitz Anna Katharina, Nawroth Roman, Maurer Tobias, Tulic Cane, Simic Tatjana, Junker Kerstin, Horstmann Marcus, Harving Niels, Petersen Astrid Christine, Calle M Luz, Steyerberg Ewout W, Beukers Willemien, van Kessel Kim E M, Jensen Jørgen Bjerggaard, Pedersen Jakob Skou, Malmström Per-Uno, Malats Núria, Real Francisco X, Zwarthoff Ellen C, Ørntoft Torben Falck, Dyrskjøt Lars

Abstract excerpt

Non-muscle-invasive bladder cancer (NMIBC) is a heterogeneous disease with widely different outcomes. We performed a comprehensive transcriptional analysis of 460 early-stage urothelial carcinomas and showed that NMIBC can be subgrouped into three major classes with basal- and luminal-like characteristics and different clinical outcomes. Large differences in biological processes such as the cell cycle,...

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PMID: 27321955
DOI: 10.1016/j.ccell.2016.05.004

Genes

ERBB2

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