Article
Pan-urologic cancer genomic subtypes that transcend tissue of origin.
Nature communications - 4 Aug 2017
Chen Fengju, Zhang Yiqun, Bossé Dominick, Lalani Aly-Khan A, Hakimi A Ari, Hsieh James J, Choueiri Toni K, Gibbons Don L, Ittmann Michael, Creighton Chad J
Abstract excerpt
Urologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of multidimensional and comprehensive molecular characterization (including DNA methylation and copy number, and RNA and protein expression). Tissue dominant effects are...
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