Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SWI/SNF-associated molecular subtypes reshape tumor microenvironmental features and inform precision therapeutic strategies in bladder cancer.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Qi Tiezheng, Yang Wenqi, Liu Rongxin, Deng Dingshan, Liu Xianghu

Abstract excerpt

Background: Bladder cancer (BLCA) is a malignant tumor characterized by pronounced molecular and immunological heterogeneity. Despite continuous advances in immunotherapy and targeted treatment, clinical outcomes vary substantially, and effective molecular stratification and predictive biomarkers remain lacking. The SWI/SNF chromatin-remodeling complex regulates chromatin accessibility and gene transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Assembly and Disassembly
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy

Share to Precision Medicine

Share to Retinoblastoma Binding Proteins

Share to Tumor Microenvironment

Share to Ubiquitin-Protein Ligases

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41789425
DOI: 10.3389/fcimb.2026.1774929
PMCID: PMC12957257

Genes

FGFR3
KDM6A
RB1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SWI/SNF-associated molecular subtypes reshape tumor microenvironmental features and inform precision therapeutic strategies in bladder cancer.PMID 41789425Read ↗

The associations of SNF5 with prognosis and immune responses in bladder cancerSemantic proximity Read ↗

Integrating single-cell RNA-seq to identify fibroblast-based molecular subtypes for predicting prognosis and therapeutic response in bladder cancerSemantic proximity Read ↗

Collaborating single-cell and bulk RNA sequencing for comprehensive characterization of the intratumor heterogeneity and prognostic model development for bladder cancerSemantic proximity Read ↗

scRNA-seq reveals epithelial heterogeneity in bladder cancer and establishes a cancer stem cell prognostic modelSemantic proximity Read ↗

Single-cell and bulk RNA-sequence identiﬁed ﬁbroblasts signature and CD8 + T-cell - ﬁbroblast subtype predicting prognosis and immune therapeutic response of bladder cancer, based on machine learning: bioinformatics multi-omics studySemantic proximity Read ↗

Delineating SWI/SNF gene and subtype expression in cancer.Semantic proximity Read ↗

SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial CarcinomaSemantic proximity Read ↗

Construction of a Novel T Cell Subtype with Immunotherapeutic Value in Bladder Cancer and a Neural Network-Based Prognostic ModelSemantic proximity Read ↗

Dysregulation of EMT Drives the Progression to Clinically Aggressive Sarcomatoid Bladder CancerSemantic proximity Read ↗

Assessment of SWI/SNF chromatin remodeling complex related genes as potential biomarkers and therapeutic targets in pan-cancerSemantic proximity Read ↗

Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic modelSemantic proximity Read ↗

Integrating Stemness Features and Immune Microenvironment in a Prognostic Model for Bladder Cancer TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.