Article

Reduced translation efficiency due to novel splicing variants in 5′ untranslated region and identification of novel cis-regulatory elements in canine and human BRCA2

2020-12-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Breast cancer 2, early onset (<italic>BRCA2</italic>) is a tumor suppressor gene. The protein encoded by this gene plays an important role in homologous recombination (HR)-mediated DNA repair. Deleterious mutations in <italic>BRCA2 </italic>and downregulation of its expression have been associated with tumorigenesis in dogs and humans. Thus, regulation of BRCA2...

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Literature Corpus work: 89df232c-72fd-52ba-afde-0883b1b7b41c
DOI: 10.21203/rs.3.rs-32784/v3

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