Article
Reduced canine BRCA2 expression levels in mammary gland tumors.
BMC veterinary research - 23 Jul 2015
Yoshikawa Yasunaga, Morimatsu Masami, Ochiai Kazuhiko, Ishiguro-Oonuma Toshina, Wada Seiichi, Orino Koichi, Watanabe Kiyotaka
Abstract excerpt
BACKGROUND: Mammary tumors are the most common tumor type in intact female dogs. Recently, the breast cancer 2 early onset (BRCA2) gene was proposed to be associated with tumorigenesis in dogs. The expression level of BRCA2 is important for its DNA repair function in mammalian cells, and its expression level is linked to tumorigenesis in mammary tissue. However, the expression of canine BRCA2 in mammary tumors is...
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