Article
Complete sequencing of full-length canine ataxia telangiectasia mutated mRNA and characterization of its putative promoter.
Veterinary immunology and immunopathology - 15 Apr 2009
Gentilini Fabio, Turba Maria Elena, Forni Monica, Cinotti Stefano
Abstract excerpt
Ataxia telangiectasia mutated (ATM) protein is considered a "caretaker" of the genome integrity and a defective ATM has been correlated with increased cancer risk in human beings. In an effort to explore the reliability of dog as a spontaneous animal model of genetic susceptibility to lymphoid malignancies, we have carried out the complete sequencing of the canine ATM mRNA. 5' RACE analysis and sequencing were...
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