Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy.

BMC veterinary research - 31 Jan 2020

Thumser-Henner Pauline, Nytko Katarzyna J, Rohrer Bley Carla

Abstract excerpt

Dogs develop cancer spontaneously with age, with breed-specific risk underlying differences in genetics. Mammary tumors are reported as the most frequent neoplasia in intact female dogs. Their high prevalence in certain breeds suggests a genetic component, as it is the case in human familial breast cancer, distinctly in BRCA2-associated cancers. However, the molecular genetics of BRCA2 in the pathogenesis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dog Diseases
Share to Dogs
Share to Genes, BRCA2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Animal

Share to Mutation

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 32005245
DOI: 10.1186/s12917-020-2247-4
PMCID: PMC6995156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations of BRCA2 in canine mammary tumors and their targeting potential in clinical therapy.PMID 32005245Read ↗

Exploring the Therapeutic Potential of BRCA1 and BRCA2 as Targets in Canine Oncology: A Comprehensive Review of Their Role in Cancer Development and TreatmentSemantic proximity Read ↗

DNA damage response proteins in canine cancer as potential research targets in comparative oncology.Semantic proximity Read ↗

Molecular biological aspects on canine and human mammary tumors.Semantic proximity Read ↗

PARP inhibitor olaparib induces DNA damage and acts as a drug sensitizer in an in vitro model of canine hematopoietic cancerSemantic proximity Read ↗

Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients.Semantic proximity Read ↗

Potential agnostic role of BRCA alterations in patients with several solid tumors: One for all, all for one?Semantic proximity Read ↗

Reviewing the characteristics of BRCA and PALB2-related cancers in the precision medicine eraSemantic proximity Read ↗

Liquid biopsy can detect BRCA2 gene variants in female dogs with mammary neoplasia.Semantic proximity Read ↗

Somatic SNPs of the BRCA2 gene at the fragments encoding RAD51 binding sites of canine mammary tumors.Semantic proximity Read ↗

A comprehensive analysis of BRCA2 gene: focus on mechanistic aspects of its functions, spectrum of deleterious mutations, and therapeutic strategies targeting BRCA2-deficient tumors.Semantic proximity Read ↗

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogsSemantic proximity Read ↗

Homologous Recombination Defects and Mutations in DNA Damage Response (DDR) Genes Besides BRCA1 and BRCA2 as Breast Cancer Biomarkers for PARP Inhibitors and Other DDR Targeting Therapies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.