Article
Establishment of a PCR analysis method for canine BRCA2.
BMC research notes - 3 Apr 2012
Yoshikawa Yasunaga, Morimatsu Masami, Ochiai Kazuhiko, Okuda Kento, Taoda Takahiro, Chikazawa Seishiro, Shimamura Asako, Omi Toshinori, Bonkobara Makoto, Orino Koichi, Watanabe Kiyotaka
Abstract excerpt
BACKGROUND: Mammary tumors are the most common tumor type in both human and canine females. In women, carriers of mutations in BRCA2, a tumor suppressor gene product, have a higher risk of breast cancer. Canine BRCA2 has also been suggested to have a relationship with mammary tumors. However, clearly deleterious BRCA2 mutations have not been identified in any canine mammary tumors, as appropriate methods to...
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