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Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease

1 Sept 2023

Abstract excerpt

The hallmark of Alzheimer's disease (AD) is the progressive accumulation of misfolded proteins, specifically beta-amyloid (Aβ) and Tau, leading to neurotoxicity and impaired neuronal function.1 Impaired mitophagy in AD contributes to protein buildup and subsequent neuronal damage.2 Mitophagy enhancers are investigated as potential therapeutic interventions for AD.3, 4 Deoxytrillenoside CA (DTCA) and...

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PMID: 37658612
DOI: 10.1002/ctm2.1390

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