Article

O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control

2024-02-28

Abstract excerpt

O-GlcNAcylation is an evolutionary conserved post-translational modification implicated in neurodevelopment. Missense variants of O-GlcNAc transferase (OGT) are causal for the intellectual disability syndrome OGT Congenital Disorder of Glycosylation (OGT-CDG). The observation of microcephaly in OGT-CDG patients suggests that dysregulation of the cell cycle and aberrant neurogenesis may contribute to disease aetiol...

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Literature Corpus work: 89bfa9db-a812-5c16-987d-1e4d25d9e189
DOI: 10.1101/2024.02.28.582457

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