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Article

O-GlcNAc transferase congenital disorder of glycosylation (OGT-CDG): Potential mechanistic targets revealed by evaluating the OGT interactome.

The Journal of biological chemistry - 1 Sept 2024

Mayfield Johnathan M, Hitefield Naomi L, Czajewski Ignacy, Vanhye Lotte, Holden Laura, Morava Eva, van Aalten Daan M F, Wells Lance

Abstract excerpt

O-GlcNAc transferase (OGT) is the sole enzyme responsible for the post-translational modification of O-GlcNAc on thousands of target nucleocytoplasmic proteins. To date, nine variants of OGT that segregate with OGT Congenital Disorder of Glycosylation (OGT-CDG) have been reported and characterized. Numerous additional variants have been associated with OGT-CDG, some of which are currently undergoing...

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Identifiers

PMID: 39059494
DOI: 10.1016/j.jbc.2024.107599
PMCID: PMC11381892

Genes

OGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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