Article

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability

2023-08-24

Abstract excerpt

O-GlcNAcylation is a protein modification that is critical for vertebrate development, catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAcase (OGA). Missense mutations in OGT have recently been shown to segregate with a syndromic form of intellectual disability, OGT-linked Congenital Disorder of Glycosylation (OGT-CDG). Although OGT-CDG suggests a critical role of O-GlcNAcylation in neurodevelopment...

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Literature Corpus work: cf38ec64-03dd-5840-86d8-190e4b0723dd
DOI: 10.1101/2023.08.23.554427

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