Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability.

eLife - 13 Nov 2024

Czajewski Ignacy, Swain Bijayalaxmi, Xu Jiawei, McDowall Laurin, Ferenbach Andrew T, van Aalten Daan M F

Abstract excerpt

O-GlcNAcylation is an essential intracellular protein modification mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Recently, missense mutations in OGT have been linked to intellectual disability, indicating that this modification is important for the development and functioning of the nervous system. However, the processes that are most sensitive to perturbations in O-GlcNAcylation remain to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease Models, Animal
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Intellectual Disability

Share to N-Acetylglucosaminyltransferases

Share to Neurogenesis

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 39535175
DOI: 10.7554/eLife.90376
PMCID: PMC11623933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability.PMID 39535175Read ↗

Rescuable sleep and synaptogenesis phenotypes in a <i>Drosophila</i> model of O-GlcNAc transferase intellectual disabilitySemantic proximity Read ↗

Intellectual disability-associated disruption of O-GlcNAcylation impairs neuronal development and cognitive function in <i>Drosophila</i>Semantic proximity Read ↗

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disabilitySemantic proximity Read ↗

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability.Semantic proximity Read ↗

Drosophila O-GlcNAcase Mutants Reveal an Expanded Glycoproteome and Novel Growth and Longevity Phenotypes.Semantic proximity Read ↗

Genetic rescue of pathogenic O-GlcNAc dyshomeostasis associated with microcephaly and motor deficitsSemantic proximity Read ↗

Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivitySemantic proximity Read ↗

The O-GlcNAc cycling in neurodevelopment and associated diseases.Semantic proximity Read ↗

Intellectual disability and neurogenesis defects associated with increased turnover of an O-GlcNAcase variantSemantic proximity Read ↗

Brain O-GlcNAcylation: From Molecular Mechanisms to Clinical Phenotype.Semantic proximity Read ↗

O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.Semantic proximity Read ↗

Systematic mapping of O-GlcNAc transferase and O-GlcNAcase defines disease-associated variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.