Article

Chromatin State Distinguishes Injury-Responsive from State-Stabilizing Transcriptional Programs in Hybrid Hepatocytes

2026-05-07

Abstract excerpt

Liver injury induces rapid transcriptional responses in hepatocytes, yet the chromatin features that distinguish injured hepatocytes from healthy hepatocytes remain poorly understood. Using an integrated functional genomics approach combining bulk RNA-seq, ATAC-seq, and CUT&Tag profiling of H3K27ac and H3K27me3, we define the transcriptional and chromatin landscape of Sox9 -expressing hepatocytes, which exhibit g...

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Literature Corpus work: 2df877aa-62c9-5d1e-8bb9-341dcd4dcf23
DOI: 10.64898/2026.05.04.722673

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