Article

Sex-specific KDM6A-HNF4A-CREBH network controls lipoprotein cholesterol metabolism and atherosclerosis via epigenetic reprograming of hepatocytes

2026-01-05

Abstract excerpt

<title>Abstract</title> <p>The liver is a central organ in the maintenance of lipid metabolism. It coordinates cholesterol uptake, biosynthesis, excretion and clearance through an intricated transcription network defined in the epigenetic level by transcription factors and coregulators. Those networks differ between males and females, resulting in marked sex differences in lipoprotein patterns and risk of develop...

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Literature Corpus work: 37ada9e4-6738-54b6-992f-0d327a3bf8cf
DOI: 10.21203/rs.3.rs-6065505/v1

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