Plasma Growth Hormone Pulses Induce Male-biased Pulsatile Chromatin Opening and Epigenetic Regulation in Adult Mouse Liver

Abstract excerpt

Sex-differences in plasma growth hormone (GH) profiles, pulsatile in males and persistent in females, regulate sex differences in hepatic STAT5 activation linked to sex differences in gene expression and liver disease susceptibility, but little is understood about the fundamental underlying, GH pattern-dependent regulatory mechanisms. Here, DNase hypersensitivity site (DHS) analysis of liver chromatin accessibilit...

Topics

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• Cancer, Hypoxia, and Metabolism
• Cytokine Signaling Pathways and Interactions
• FOXO transcription factor regulation
• Growth Hormone and Insulin-like Growth Factors
• Hormonal Regulation and Hypertension
• Lipid metabolism and disorders
• Liver Disease Diagnosis and Treatment
• Pharmacogenetics and Drug Metabolism

Identifiers and source

Literature Corpus work

adc0f4f3-ed71-5430-b3db-95d5ffbfdcbe

DOI

10.1101/2023.08.21.554153