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Article

Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease

21 Nov 2023

Abstract excerpt

BACKGROUND: Huntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum is a major hallmark of the disease. Approximately 30% of those glutamatergic inputs come from thalamic nuclei. Foxp2 is a transcription factor involved in cell differentiation and reported low in patients with HD. However, the role of the Foxp2 in the thalamus in HD remains...

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PMID: 37987826
DOI: 10.1007/s00018-023-05015-z

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