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Article

SPAG17 Is Required for Male Germ Cell Differentiation and Fertility

21 Apr 2018

Abstract excerpt

Spag17 encodes a protein present in the axoneme central pair complex of motile cilia and flagella. A mutation in this gene has been reported to be associated with infertility caused by defects in sperm motility. Here, we report that Spag17 knockout mice are infertile because of a severe defect in spermatogenesis. The histological evaluation of testis sections from mutant mice revealed seminiferous tubules with...

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PMID: 29690537
DOI: 10.3390/ijms19041252

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