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Article

Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis

2021-11-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> To identify key disease pathways driving conventional dendritic cell (cDC) alterations in Systemic Sclerosis (SSc). <h4>Methods</h4> Transcriptomic profiling was performed on peripheral blood CD1c+ cDCs (cDC2s) isolated from 12 healthy donors and 48 SSc patients with all major disease subtypes. Differential expression analysis comparing the different SSc subtypes and health...

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Literature Corpus work
899c4d6c-c84e-5692-81c1-a0fc94716c40
DOI
10.1101/2021.11.08.467605
Open publication

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