Article

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells

2025-07-12

Abstract excerpt

Adenosine-to-inosine (A-to-I) editing is an endogenous RNA modification in eukaryotes, catalyzed by adenosine deaminases acting on RNA (ADARs). This modification modulates the gene expression by influencing splicing, RNA stability, and coding potential, depending on the site of editing. Although recent studies suggest a crosstalk between A-to-I editing and transcripts involved in DNA repair, the extent and functio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8994b98c-ed24-5829-939f-967f495858ea
DOI: 10.1101/2025.07.11.664482

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cellsDOI 10.1101/2025.07.11.664482Read

Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human DiseasesSemantic proximity Read

RNA Editing Dynamically Rewrites the Cancer Code.Semantic proximity Read

Elevated RNA Editing Activity Is a Major Contributor to Transcriptomic Diversity in Tumors.Semantic proximity Read

The RNA Editome of Esophageal Squamous Cell Carcinoma Identifies an ADAR1-CDK13 Editing Feedback Loop Mediating cGAS–STING Activation in Early TumorigenesisSemantic proximity Read

RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia.Semantic proximity Read

Multiscale RNA editing analysis reveals cell type–specific regulatory programs across disease states in acute myeloid leukemiaSemantic proximity Read

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoformsSemantic proximity Read

An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.Semantic proximity Read

Chromatin state shapes site-specific A-to-I RNA editingSemantic proximity Read

ADARs, RNA editing and more in hematological malignanciesSemantic proximity Read

Pan-cancer RNA editing activity reveals complex editing functions and cancer immunotherapy biomarkersSemantic proximity Read

Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variablesSemantic proximity Read