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Article

An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks.

Molecular cancer - 8 Sept 2021

Ramírez-Moya Julia, Miliotis Christos, Baker Allison R, Gregory Richard I, Slack Frank J, Santisteban Pilar

Abstract excerpt

BACKGROUND: Adenosine deaminases acting on RNA (ADARs) modify many cellular RNAs by catalyzing the conversion of adenosine to inosine (A-to-I), and their deregulation is associated with several cancers. We recently showed that A-to-I editing is elevated in thyroid tumors and that ADAR1 is functionally important for thyroid cancer cell progression. The downstream effectors regulated or edited by ADAR1 and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34496885
DOI: 10.1186/s12943-021-01401-y
PMCID: PMC8424981

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