Article

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms

2021-11-24

Abstract excerpt

Adenosine deaminase acting on RNA (ADAR) (also known as ADAR1) promotes A-to-I conversion in double-stranded and highly structured RNAs. ADAR1 has two isoforms transcribed from different promoters: ADAR1p150, which is mainly cytoplasmic and interferon-inducible, and constitutively expressed ADAR1p110 that is primarily localized in the nucleus. Mutations in ADAR1 cause Aicardi – Goutières syndrome (AGS), a severe a...

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Literature Corpus work: c7732bb8-d0a2-53b3-a1eb-ce9a3cad3bf7
DOI: 10.1101/2021.11.24.469911

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