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Article

Haploinsufficiency of akt1 prolongs the lifespan of mice.

PloS one - 1 Jan 2013

Nojima Aika, Yamashita Masakatsu, Yoshida Yohko, Shimizu Ippei, Ichimiya Harumi, Kamimura Naomi, Kobayashi Yoshio, Ohta Shigeo, Ishii Naoaki, Minamino Tohru

Abstract excerpt

There is increasing evidence that nutrient-sensing machinery is critically involved in the regulation of aging. The insulin/insulin-like growth factor-1 signaling pathway is the best-characterized pathway with an influence on longevity in a variety of organisms, ranging from yeast to rodents. Red...

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Identifiers

PMID: 23935948
DOI: 10.1371/journal.pone.0069178
PMCID: PMC3728301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23935948-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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