Article

Single-cell Transcriptome Profiling of Post-treatment and Treatment-naïve Colorectal Cancer: Insights into Putative Mechanisms of Chemoresistance

2024-09-27

Abstract excerpt

Drug resistance remains a major clinical challenge in the treatment of colorectal cancer (CRC) with conventional chemotherapy. Analyzing changes within tumor cells and tumor microenvironment (TME) after treatment and in metastases is essential to understanding how resistance develops. In this study, we analyzed scRNA-seq data from 56 CRCs including treatment-naïve tumors and tumors treated with standard chemothera...

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Identifiers and source

Literature Corpus work: 89820991-fa73-57f6-8855-187a83adacef
DOI: 10.1101/2024.09.26.614712

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