Article

Alpha-synuclein null mutation exacerbates the phenotype of a model of Menkes disease in female mice

2023-11-17

Abstract excerpt

Genetic modifier screens provide a useful tool, in diverse organisms from Drosophila to C. elegans and mice, for recovering new genes of interest that may reduce or enhance a phenotype of interest. This study reports a modifier screen, based on N-ethyl-N-nitrosourea (ENU) mutagenesis and outcrossing, designed to increase understanding of the normal function of murine α-synuclein ( Snca ). Human SNCA was the fi...

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Literature Corpus work: 89806b49-f3c1-53d1-8863-4f07ef775c9b
DOI: 10.1101/2023.11.15.567255

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