Article

Context-dependent ATP7 Interactions with Parkinson’s Disease-associated Genes Modulate Copper Homeostasis Phenotypes

2026-02-04

Abstract excerpt

Copper is an essential micronutrient required by enzymes that catalyze oxygen-dependent reactions, but toxic in excess. Mutations in the ATP7A and ATP7B copper transporters cause neuropsychiatric symptoms and neurodegeneration by mechanisms that remain to be elucidated. We previously reported that the ATP7A biochemical interactome is enriched in Parkinson’s disease (PD) and neurodegeneration associated proteins, y...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f65fc328-6ad5-5f00-bab8-d25f1637ad8f
DOI: 10.64898/2026.02.02.703386

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Context-dependent ATP7 Interactions with Parkinson’s Disease-associated Genes Modulate Copper Homeostasis PhenotypesDOI 10.64898/2026.02.02.703386Read

The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factorsSemantic proximity Read

In Vivo Modeling of the Pathogenic Effect of Copper Transporter Mutations That Cause Menkes and Wilson Diseases, Motor Neuropathy, and Susceptibility to Alzheimer's Disease.Semantic proximity Read

Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial ContentSemantic proximity Read

Rare Disease Mechanisms Identified by Genealogical Proteomics of Copper Homeostasis Mutant Pedigrees.Semantic proximity Read

Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7.Semantic proximity Read

Polarized trafficking and copper transport activity of ATP7B: A mutational approach to establish genotype-phenotype correlation in Wilson disease.Semantic proximity Read

A glimpse into the regulation of the Wilson disease protein, ATP7B, sheds light on the complexity of mammalian apical trafficking pathways.Semantic proximity Read

Copper and Zinc Homeostasis: Lessons from Drosophila melanogasterSemantic proximity Read

[From gene to disease: copper-transporting P ATPases alteration].Semantic proximity Read

Atp7b deficiency induces zebrafish eye developmental defects.Semantic proximity Read

Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.Semantic proximity Read