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Article

Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression.

Human molecular genetics - 15 Feb 2015

Gispert Suzana, Brehm Nadine, Weil Jonas, Seidel Kay, Rüb Udo, Kern Beatrice, Walter Michael, Roeper Jochen, Auburger Georg

Abstract excerpt

The common age-related neurodegeneration of Parkinson's disease can result from dominant causes like increased dosage of vesicle-associated alpha-synuclein (SNCA) or recessive causes like deficiency of mitophagy factor PINK1. Interactions between these triggers and their convergence onto shared pathways are crucial, but currently conflicting evidence exists. Here, we crossed previously characterized mice with...

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Source

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Identifiers

PMID: 25296918
DOI: 10.1093/hmg/ddu520
PMCID: PMC4986551

Genes

SNCA
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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