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Article

Molecular and biochemical characterization of Mottled-dappled, an embryonic lethal Menkes disease mouse model.

Molecular genetics and metabolism - 1 Dec 2014

Haddad Marie Reine, Patel Keyur D, Sullivan Patricia H, Goldstein David S, Murphy Kevin M, Centeno Jose A, Kaler Stephen G

Abstract excerpt

Mottled-dappled (Mo-dp) is a mouse model of Menkes disease caused by a large, previously uncharacterized deletion in the 5' region of Atp7a, the mouse ortholog of ATP7A. Affected mutants die in utero at embryonic day 17, and show bending and thickening of the ribs and distortion of the pectoral and pelvic girdles and limbs. To characterize this allele, we designed a custom 4x180K microarray on the mouse X...

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Identifiers

PMID: 25456742
DOI: 10.1016/j.ymgme.2014.10.001
PMCID: PMC4259894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular and biochemical characterization of Mottled-dappled, an embryonic lethal Menkes disease mouse model.PMID 25456742Read ↗

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