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Article

Molecular chaperones: Guardians of tumor suppressor stability and function.

Oncotarget - 1 Oct 2024

Heritz Jennifer A, Backe Sarah J, Mollapour Mehdi

Abstract excerpt

The term 'tumor suppressor' describes a widely diverse set of genes that are generally involved in the suppression of metastasis, but lead to tumorigenesis upon loss-of-function mutations. Despite the protein products of tumor suppressors exhibiting drastically different structures and functions, many share a common regulatory mechanism-they are molecular chaperone 'clients'. Clients of molecular chaperones...

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Share to FLCN gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 39352796
DOI: 10.18632/oncotarget.28653
PMCID: PMC11444336

Genes

FLCN
FNIP1
TSC1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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