Article

Progressive impairment of directional and spatially precise trajectories by TgF344-AD Rats in the Morris Water Task

2018-03-15

Abstract excerpt

Spatial navigation is impaired in early stages of Alzheimer’s disease (AD), and may be a defining behavioral marker of preclinical AD. Nevertheless, limitations of diagnostic criteria for AD and within animal models of AD make characterization of preclinical AD difficult. A new rat model (TgF344-AD) of AD overcomes many of these limitations, though spatial navigation has not been comprehensively assessed. Using th...

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Literature Corpus work: 89285517-7f37-5bb2-8548-c1cda0f4c40c
DOI: 10.1101/282392

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