Article

Motor deficits in the McGill-R-Thy1-APP transgenic rat model of Alzheimer’s Disease

2025-04-26

Abstract excerpt

The McGill-R-Thy1-APP rat is a transgenic model of Alzheimer’s Disease (AD) which expresses APP with two mutations found in cases of familial AD, resulting in the development of amyloid pathology and cognitive deficits. Motor deficits are common symptoms of AD, emerging early in the disease, and are correlated with AD neuropathology and cognitive symptoms. This study evaluated heterozygous and homozygous McGill-R-...

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Literature Corpus work: 75efb9f0-2261-5615-9e54-494b1a5cc4df
DOI: 10.1101/2025.04.24.650385

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