Article

Multi-ancestry proteogenomic analysis identifies risk proteins for intracranial aneurysms

2025-11-13

Abstract excerpt

<h4>Background</h4> Intracranial aneurysm (IA) and its complication, subarachnoid hemorrhage (SAH), cause morbidity and mortality, yet no preventative pharmacotherapies exist. Genome-wide association studies (GWAS) have identified risk loci for IA and SAH, but the causal proteins and pathways that connect genetic risk to aneurysm biology remain unclear. <h4>Methods</h4> We performed ancestry-stratified GWAS meta...

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Literature Corpus work: 890e2e77-58da-526f-9040-4678638cad1a
DOI: 10.1101/2025.11.11.25339992

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