Article
PRCP is a promising drug target for intracranial aneurysm rupture supported via multi-omics analysis.
Stroke and vascular neurology - 29 Apr 2025
Wu Jinghao, Mei Yunyun, Li XinYu, Yu Wen-Kai, Zhou Zi Han, Yang Yinghao, Niu Pengpeng, Wang Yunchao, Shi Chang-He, Zhu Hanghang, He Wenjun, Gao Yuan, Xu Yuming, Li Yusheng
Abstract excerpt
BACKGROUND: Cerebral aneurysms are life-threatening cerebrovascular disorders. Currently, there are no effective treatments for preventing disease progression. Mendelian randomisation (MR) is widely used to repurify licensed drugs and identify new therapeutic targets. Therefore, this study aims to investigate effective drug targets for preventing the formation and rupture of cerebral aneurysms and analyse their...
Topics
- Humans
- Intracranial Aneurysm
- Aneurysm, Ruptured
- Genetic Predisposition to Disease
- Proteomics
- Quantitative Trait Loci
- Carboxypeptidases
- Phenotype
- Mendelian Randomization Analysis
- Risk Factors