Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiomics genetic insights into potential molecular targets for intracranial aneurysm.

Stroke and vascular neurology - 4 Mar 2026

Jia Yitong, Lin Fa, Li Runting, Yang Yi, Chen Xiaolin, Wang Shuo

Abstract excerpt

BACKGROUND: This study aimed to identify multiomics therapeutic targets for aneurysmal subarachnoid haemorrhage (aSAH) and unruptured intracranial aneurysm (uIA) using Mendelian randomisation (MR), summary-data-based MR (SMR) and postanalysis methods. METHODS: Significant genetic variables were extracted from multiple databases, including Expression Quantitative Trait Loci (eQTL) from eQTLGen and Genotype-Tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Genetic
Share to DNA Methylation
Share to Intracranial Aneurysm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Molecular Docking Simulation

Share to Molecular Targeted Therapy

Share to Multiomics

Share to Subarachnoid Hemorrhage

Source

Open in PubMed Open full text

Identifiers

PMID: 40639910
DOI: 10.1136/svn-2025-004175
PMCID: PMC13019052

Genes

PRCP
PSMA4
RELT
TNFSF12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiomics genetic insights into potential molecular targets for intracranial aneurysm.PMID 40639910Read ↗

PRCP is a promising drug target for intracranial aneurysm rupture supported via multi-omics analysis.Semantic proximity Read ↗

Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics.Semantic proximity Read ↗

Multi-ancestry proteogenomic analysis identifies risk proteins for intracranial aneurysmsSemantic proximity Read ↗

Genetic susceptibility and potential therapeutic targets of unruptured intracranial aneurysms: A genome-wide study based on Mendelian randomization.Semantic proximity Read ↗

Genome-Wide Association Study and Fine Mapping Uncover Key Genetic Loci and Credible Genes of Intracranial Aneurysm and Aneurysmal Subarachnoid Hemorrhage.Semantic proximity Read ↗

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.Semantic proximity Read ↗

Promising Therapeutic Targets for Intracranial Aneurysms: A Systematic Druggable Genome-Wide Mendelian Randomization.Semantic proximity Read ↗

Investigating Potential Drug Targets in Intracranial Aneurysms through Mendelian Randomization and Transcriptome AnalysesSemantic proximity Read ↗

Novel insight into m6A regulator-mediated methylation modification patterns and immune characteristics in intracranial aneurysmSemantic proximity Read ↗

A Multi-Scale Integrative Framework Identifies THBS1 as a Master Diagnostic Hub and Prioritises Small-Molecule Therapeutics for Subarachnoid HemorrhageSemantic proximity Read ↗

Dissecting the Genetic Architecture of Intracranial AneurysmsSemantic proximity Read ↗

Integrative analysis of single-cell sequencing, bulk transcriptomics and experimental verification reveals key molecular mechanisms of vascular smooth muscle cells involved in intracranial aneurysm progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.