Article
Multiomics genetic insights into potential molecular targets for intracranial aneurysm.
Stroke and vascular neurology - 4 Mar 2026
Jia Yitong, Lin Fa, Li Runting, Yang Yi, Chen Xiaolin, Wang Shuo
Abstract excerpt
BACKGROUND: This study aimed to identify multiomics therapeutic targets for aneurysmal subarachnoid haemorrhage (aSAH) and unruptured intracranial aneurysm (uIA) using Mendelian randomisation (MR), summary-data-based MR (SMR) and postanalysis methods. METHODS: Significant genetic variables were extracted from multiple databases, including Expression Quantitative Trait Loci (eQTL) from eQTLGen and Genotype-Tissue...
Topics
- Humans
- Intracranial Aneurysm
- Subarachnoid Hemorrhage
- Genetic Predisposition to Disease
- Molecular Docking Simulation
- DNA Methylation
- Phenotype
- Quantitative Trait Loci
- Mendelian Randomization Analysis
- Databases, Genetic
- Risk Factors
- Molecular Targeted Therapy
- Genome-Wide Association Study