Article

Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights<i>PCSK9</i>as a therapeutic target

2022-05-29

Abstract excerpt

<h4>Summary</h4> Abdominal aortic aneurysm (AAA) is a common disease with significant heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 144 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis was able to explain AAA beyond clinical risk factors. Genes at AAA risk loci indicate in...

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Literature Corpus work: 46f16e81-1f47-5171-b9a9-7d124b662fbe
DOI: 10.1101/2022.05.27.22275607

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