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Article

Multinational Genome-Wide Association Study and Functional Genomics Analysis Implicates Decreased SIRT3 Expression Underlying Intracranial Aneurysm Risk.

Neurosurgery - 1 Oct 2022

Hale Andrew T, He Jing, Jones Jesse

Abstract excerpt

BACKGROUND: The genetic mechanisms regulating intracranial aneurysm (IA) formation and rupture are largely unknown. To identify germline-genetic risk factors for IA, we perform a multinational genome-wide association study (GWAS) of individuals from the United Kingdom, Finland, and Japan. OBJECTIVE: To identify a shared, multinational genetic basis of IA. METHODS: Using GWAS summary statistics from UK Biobank,...

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Source

Identifiers

PMID: 35838494
DOI: 10.1227/neu.0000000000002082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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