Article

PhenoGenX: A Dual-Engine, Data-Driven Platform for HIV-1 Drug Resistance Interpretation Integrating Ensemble Machine Learning and Rule-Based Algorithms

2026-03-10

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> : HIV-1 drug resistance (HIVDR) interpretation relies on expert rule-based algorithms that translate mutation–drug relationships into clinical categories but do not directly model phenotypic susceptibility and may have limited sensitivity to complex mutational patterns. We developed PhenoGenX (PGX), a dual-engine platform combining a phenotype-trained machine...

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Literature Corpus work: 88f172cd-ae25-59d8-aa96-c70a5f262419
DOI: 10.21203/rs.3.rs-9056343/v1

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