Article

Injectable borax-loaded alginate hydrogels reduce muscle atrophy, modulate inflammation, and generate neuroprotection in the SOD1 <sup>G93A</sup> mouse model of ALS via activation of the IGF–Akt–mTOR axis pathway

2023-11-16

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is the most frequent and fatal condition that causes motor neuron loss and skeletal muscle paralysis. Although ALS is associated with mutations in over 40 genes, its etiology remains largely elusive without a cure or effective treatment. Historically considered the prototype of motor neuron diseases, ALS is defined today as a multisystem disorder that presents several changes in...

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Literature Corpus work: 88e70e08-b235-550e-aa50-a700f469a226
DOI: 10.1101/2023.11.14.567052

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