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Article

Heparin-Mimicking Polymer-Based In Vitro Platform Recapitulates In Vivo Muscle Atrophy Phenotypes.

International journal of molecular sciences - 2 Mar 2021

Kim Hyunbum, Jeong Ji Hoon, Fendereski Mona, Lee Hyo-Shin, Kang Da Yeon, Hur Sung Sik, Amirian Jhaleh, Kim Yunhye, Pham Nghia Thi, Suh Nayoung, Hwang Nathaniel Suk-Yeon, Ryu Seongho, Yoon Jeong Kyo, Hwang Yongsung

Abstract excerpt

The cell-cell/cell-matrix interactions between myoblasts and their extracellular microenvironment have been shown to play a crucial role in the regulation of in vitro myogenic differentiation and in vivo skeletal muscle regeneration. In this study, by harnessing the heparin-mimicking polymer, poly(sodium-4-styrenesulfonate) (PSS), which has a negatively charged surface, we engineered an in vitro cell culture...

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Identifiers

PMID: 33801235
DOI: 10.3390/ijms22052488
PMCID: PMC7957884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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