Article

Effect of curcumin-loaded polydopamine nanoparticles on the expression of AKT, HDAC6, and HSF1 in Trembler-J Schwann cell cultures

2026-06-19

Abstract excerpt

<title>Abstract</title> <p>Charcot-Marie-Tooth is the most common progressive sensory and motor peripheral neuropathy in humans. Charcot-Marie-Tooth type 1E, a demyelinating neuropathy modeled by Trembler-J mice, affects Schwann cells due to a point mutation in the peripheral myelin protein-22 gene. Curcumin is a polyphenol extracted from the roots of Curcuma longa. Low doses of curcumin exhibit anti-inflammatory...

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Literature Corpus work: 4ca6712a-8a9c-538d-bfd9-1c381828f438
DOI: 10.21203/rs.3.rs-9452415/v1

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