Article
Contingent intramuscular boosting of P2XR7 axis improves motor function in transgenic ALS mice.
Cellular and molecular life sciences : CMLS - 22 Dec 2021
Fabbrizio Paola, D'Agostino Jessica, Margotta Cassandra, Mella Giulia, Panini Nicolò, Pasetto Laura, Sammali Eliana, Raggi Flavia, Sorarù Gianni, Bonetto Valentina, Bendotti Caterina, Nardo Giovanni
Abstract excerpt
Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder that leads to progressive degeneration of motor neurons and severe muscle atrophy without effective treatment. Most research on the disease has been focused on studying motor neurons and supporting cells of the central nervous system. Strikingly, the recent observations have suggested that morpho-functional alterations in skeletal muscle precede...
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