Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1A4V mutation.

Scientific reports - 5 Apr 2023

Marshall Katherine L, Rajbhandari Labchan, Venkatesan Arun, Maragakis Nicholas J, Farah Mohamed H

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by degeneration of upper and lower motor neurons that leads to muscle weakness, paralysis, and death, but the effects of disease-causing mutations on axonal outgrowth of neurons derived from human induced pluripotent stem cells (iPSC)-derived motor neurons (hiPSC-MN) are poorly understood. The use of hiPSC-MN is a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Axons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Motor Neurons

Share to Nerve Regeneration

Share to Neurodegenerative Diseases

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Open in PubMed Open full text

Identifiers

PMID: 37020097
DOI: 10.1038/s41598-023-31720-7
PMCID: PMC10076424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced axonal regeneration of ALS patient iPSC-derived motor neurons harboring SOD1A4V mutation.PMID 37020097Read ↗

Progress and challenges in directing the differentiation of human iPSCs into spinal motor neuronsSemantic proximity Read ↗

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death.Semantic proximity Read ↗

ALS-linked SOD1 Mutants Enhance Outgrowth, Branching, and the Formation of Actin-Based Structures in Adult Motor NeuronsSemantic proximity Read ↗

Culture of Human iPSC-Derived Motoneurons in Compartmentalized Microfluidic Devices and Quantitative Assays for Studying Axonal Phenotypes.Semantic proximity Read ↗

Neuromuscular junction‐on‐a‐chip: ALS disease modeling and read‐out development in microfluidic devicesSemantic proximity Read ↗

ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor NeuronsSemantic proximity Read ↗

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron deathSemantic proximity Read ↗

High-throughput quantitative analysis of axonal transport in cultured neurons from SOD1H46R ALS mice by using a microfluidic device.Semantic proximity Read ↗

Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Motoneuron differentiation of induced pluripotent stem cells from SOD1G93A mice.Semantic proximity Read ↗

Advances and challenges in modeling inherited peripheral neuropathies using iPSCsSemantic proximity Read ↗

Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.