Back to search

Article

Genomic-adjusted radiation dose and outcomes in radiotherapy-treated locally advanced rectal cancer: a pooled multicohort analysis including the TIMING, OPRA, and CAO/ARO/AIO-94 prospective trials

2026-08-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Treatment of locally advanced rectal cancer (LARC) increasingly varies in radiotherapy use, sequence, and intensity. Pretreatment biomarkers for the mismatch-repair-proficient majority remain limited: the biopsy-adapted Immunoscore predicts neoadjuvant response and recurrence risk, but no available biomarker estimates intrinsic tumor radiosensitivity or guides radiotherapy d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1943cf47-8e9b-594d-8092-9275ad17a24f
DOI
10.64898/2026.08.14.26360478
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genomic-adjusted radiation dose and outcomes in radiotherapy-treated locally advanced rectal cancer: a pooled multicohort analysis including the TIMING, OPRA, and CAO/ARO/AIO-94 prospective trialsDOI 10.64898/2026.08.14.26360478
GARD is a pan-cancer predictor of radiation therapy benefitSemantic proximity
Leveraging a Patient-Derived Tumoroid Platform for Precision Radiotherapy: Uncovering DNA Damage Repair Inhibitor-Mediated Radiosensitization and Therapeutic Resistance in Rectal CancerSemantic proximity
Genomic-Adjusted Radiation Dose from Bulk RNA Sequencing for Personalized RadiotherapySemantic proximity
The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.Semantic proximity
Assessing the practice of Total Neoadjuvant Therapy for rectal cancer: an online survey among Radiation Oncology Departments in Germany and German-Speaking Regions of Austria and SwitzerlandSemantic proximity
Study Protocol of A Phase II Study to Evaluate Safety and Efficacy of Neo-adjuvant Pembrolizumab and Radiotherapy in Localized Rectal CancerSemantic proximity
Total Neoadjuvant Therapy and Organ Preservation in Locally Advanced Rectal Cancer: A State-of-the-Art Systematic Review and Critical AppraisalSemantic proximity
MRI Tumor Regression Grade and Circulating Tumor DNA as Complementary Tools to Assess Response and Guide Therapy Adaptation in Rectal Cancer.Semantic proximity
Research on radiotherapy related genes and prognostic target identification of rectal cancer based on multi-omicsSemantic proximity
Exploring novel inflammation-related genetic and hematological predictors of response to neoadjuvant chemoradiotherapy in locally advanced rectal cancerSemantic proximity
New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapySemantic proximity
Tumor Resectability and Pathologic Response After Neoadjuvant Long-Course Chemoradiotherapy for Locally Advanced Rectal Cancer in a Resource-Limited SettingSemantic proximity
Select a neighboring publication to make it the new centre.