Article

Epithelial competition determines gene therapy potential to suppress Fanconi Anemia oral cancer risk

2025-03-01

Abstract excerpt

Fanconi Anemia (FA) is a heritable syndrome characterized by DNA damage repair deficits, frequent malformations and a significantly elevated risk of bone marrow failure, leukemia, and mucosal head and neck squamous cell carcinomas (HNSCC). Hematopoietic stem cell gene therapy can prevent marrow failure and lower leukemia risk, but mucosal gene therapy to lower HNSCC risk remains untested. Major knowledge gaps incl...

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Literature Corpus work: 88c23d18-3387-559b-8f8f-e1cad281f474
DOI: 10.1101/2025.02.26.640284

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